costunolide  (Merck KGaA)

Journal: Biomolecules & Therapeutics

Article Title: Unraveling Stereochemical Structure-Activity Relationships of Sesquiterpene Lactones for Inhibitory Effects on STAT3 Activation

doi: 10.4062/biomolther.2023.210

Figure Lengend Snippet: Protein-ligand docking study of sesquiterpene lactones in STAT3. (A) Domain structured of STAT3. SH2, Src homology 2; TAD, transactivation domain. (B) X-ray crystal structure of p-STAT3 homodimer. (C) Key interacting amino acid residues of pTyr705 in SH2 domain binding pocket. Hydrogen bonds were shown in black dashes. (D) The location of SH2 domain binding pocket. Selected docking poses of sesquiterpene lactones; (E) alantolactone, (F) isoalantolactone, (G) parthenolide, (H) costunolide, (I) atractylenoide I, and (J) sclareolide. Top ten most energy-minimized binding modes of (K) dehydrocostus lactone, and (L) tulipalin A were compared with those of alantolactone.

Article Snippet: Alantolactone, isoalantolactone, costunolide, dehydrocostus lactone, parthenolide, atractylenolide I, atractylenolide II, atractylenolide III, and sclareolide, were purchased from Tauto Biotech (Shanghai, China).

Techniques: Binding Assay

Journal: Plants

Article Title: Targeted Screening and Quantification of Characteristic Sesquiterpene Lactones in Ambrosia artemisiifolia L. at Different Growth Stages

doi: 10.3390/plants13152053

Figure Lengend Snippet: Characteristics of the calibration curves and limit of detection and quantification values, and results of the system suitability test. (LOD: limit of detection, LOQ: limit of quantification, RSD: relative standard deviation, RT: retention time).

Article Snippet: The sesquiterpene lactones psilostachyin ( 1 ), peruvin ( 2 ), and acetoxydihydrodamsin ( 3 ) were isolated by our group [ ]; costunolide ( 4 ) was obtained from Merck KGaA (Darmstadt, Germany; purity >97%), while isoalantolactone ( 5 ) was purchased from MedChemExpress LLC (Monmouth Junction, NJ, USA; purity 99.99%).

Techniques: Standard Deviation

Journal: Plants

Article Title: Targeted Screening and Quantification of Characteristic Sesquiterpene Lactones in Ambrosia artemisiifolia L. at Different Growth Stages

doi: 10.3390/plants13152053

Figure Lengend Snippet: Contents of marker compounds in aerial parts of A. artemisiifolia collected near Szeged, Hungary.

Article Snippet: The sesquiterpene lactones psilostachyin ( 1 ), peruvin ( 2 ), and acetoxydihydrodamsin ( 3 ) were isolated by our group [ ]; costunolide ( 4 ) was obtained from Merck KGaA (Darmstadt, Germany; purity >97%), while isoalantolactone ( 5 ) was purchased from MedChemExpress LLC (Monmouth Junction, NJ, USA; purity 99.99%).

Techniques: Marker

Journal: Plants

Article Title: Targeted Screening and Quantification of Characteristic Sesquiterpene Lactones in Ambrosia artemisiifolia L. at Different Growth Stages

doi: 10.3390/plants13152053

Figure Lengend Snippet: Contents of marker compounds in aerial parts of A. artemisiifolia collected near Nyíri, Hungary.

Article Snippet: The sesquiterpene lactones psilostachyin ( 1 ), peruvin ( 2 ), and acetoxydihydrodamsin ( 3 ) were isolated by our group [ ]; costunolide ( 4 ) was obtained from Merck KGaA (Darmstadt, Germany; purity >97%), while isoalantolactone ( 5 ) was purchased from MedChemExpress LLC (Monmouth Junction, NJ, USA; purity 99.99%).

Techniques: Marker

Journal: Plants

Article Title: Targeted Screening and Quantification of Characteristic Sesquiterpene Lactones in Ambrosia artemisiifolia L. at Different Growth Stages

doi: 10.3390/plants13152053

Figure Lengend Snippet: Correlation data between climatic factors and concentration levels of sesquiterpene lactones.

Article Snippet: The sesquiterpene lactones psilostachyin ( 1 ), peruvin ( 2 ), and acetoxydihydrodamsin ( 3 ) were isolated by our group [ ]; costunolide ( 4 ) was obtained from Merck KGaA (Darmstadt, Germany; purity >97%), while isoalantolactone ( 5 ) was purchased from MedChemExpress LLC (Monmouth Junction, NJ, USA; purity 99.99%).

Techniques: Concentration Assay